{ "_id": "6a185deeacfb0bcc41dbd102", "Package": "scPOEM", "Type": "Package", "Title": "Single-Cell Meta-Path Based Omic Embedding", "Version": "0.1.2", "Authors@R": "c(person(given = \"Yuntong\", family = \"Hou\", email = \"houyt223@gmail.com\", role = c(\"aut\",\"cre\"), comment = c(ORCID = '0009-0005-0587-4692')),\nperson(given = \"Yan\", family = \"Zhong\", email = \"yzhong@fem.ecnu.edu.cn\", role = c(\"aut\",\"ctb\"), comment = c(ORCID = '0000-0003-2412-043X')),\nperson(given = \"Yongjian\", family = \"Yang\", email = \"yjyang027@tamu.edu\", role = c(\"ctb\"), comment = c(ORCID = '0000-0002-4135-5014')),\nperson(given = \"Xinyue\", family = \"Zheng\", email = \"10235001419@stu.ecnu.edu.cn\", role = c(\"ctb\")),\nperson(given = \"James\", family = \"Cai\", email = \"jcai@tamu.edu\", role = c(\"ctb\"), comment = c(ORCID = '0000-0002-8081-6725'))\n)", "Author": "Yuntong Hou [aut, cre] (https://orcid.org/0009-0005-0587-4692),\nYan Zhong [aut, ctb] (https://orcid.org/0000-0003-2412-043X),\nYongjian Yang [ctb] (https://orcid.org/0000-0002-4135-5014),\nXinyue Zheng [ctb], James Cai [ctb]\n(https://orcid.org/0000-0002-8081-6725)", "Description": "Provide a workflow to jointly embed chromatin\naccessibility peaks and expressed genes into a shared\nlow-dimensional space using paired single-cell 'ATAC-seq'\n('scATAC-seq') and single-cell 'RNA-seq' ('scRNA-seq') data. It\nintegrates regulatory relationships among peak-peak\ninteractions (via 'Cicero'), peak-gene interactions (via Lasso,\nrandom forest, and 'XGBoost'), and gene-gene interactions (via\nprincipal component regression). 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